H2N2V1, Main, Exploration, bibRecord, 000B63

Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Identifieur interne : 000B63 ( Main/Exploration ); précédent : 000B62; suivant : 000B64

Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Auteurs : Lok Yung Chan [Hong Kong] ; Hoi Hin Kwok [Hong Kong] ; Renee Wan Yi Chan [République populaire de Chine] ; Malik Joseph Sriyal Peiris [République populaire de Chine] ; Nai Ki Mak [Hong Kong] ; Ricky Ngok Shun Wong [Hong Kong] ; Michael Chi Wai Chan [République populaire de Chine] ; Patrick Ying Kit Yue [Hong Kong]

Source :

Journal of Ethnopharmacology [ 0378-8741 ] ; 2011-08-22.

RBID : Hal:pasteur-00623719

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng is a precious traditional Chinese herbal medicine which has been utilized as herbal tonic for improving immunity. The active component, ginsenosides have been shown to possess various pharmacological functions including immunomodulation and cardiovascular protection. AIM OF THE STUDY: To investigate the immunomodulatory effect and anti-apoptotic effect of ginsenosides on avian influenza-infected human endothelial cells, and to present evidence for the cardiovascular protection by ginseng during influenza infection. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were infected with avian influenza H9N2/G1 to induce IP-10 production and cell death, cells were then incubated with ginsenosides PPT and Re. The level of IP-10 and microRNA was determined by ELISA and real-time PCR respectively. Cell death was determined by MTT, TUNEL and flow cytometry. RESULTS: Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. In addition, ginsenoside-induced cytoprotection was reflected in the increase of cell viability. Data from flow cytometry analysis and TUNEL assay also showed that ginsenoside Re could protect ECs from H9N2/G1-induced apoptosis and DNA damage. CONCLUSIONS: This report further supports the traditional belief for immunomodulatory effects of ginseng, also demonstrated the partial protective mechanism of ginsenosides on avian influenza infection and its related endothelial dysfunction.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00623719

DOI: 10.1016/j.jep.2011.08.022

Affiliations:

Hong Kong, République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000063
to stream Hal, to step Curation: 000063
to stream Hal, to step Checkpoint: 000218
to stream Main, to step Merge: 000B67
to stream Main, to step Curation: 000B63

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>ETHNOPHARMACOLOGICAL RELEVANCE: Panax ginseng is a precious traditional Chinese herbal medicine which has been utilized as herbal tonic for improving immunity. The active component, ginsenosides have been shown to possess various pharmacological functions including immunomodulation and cardiovascular protection. AIM OF THE STUDY: To investigate the immunomodulatory effect and anti-apoptotic effect of ginsenosides on avian influenza-infected human endothelial cells, and to present evidence for the cardiovascular protection by ginseng during influenza infection. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were infected with avian influenza H9N2/G1 to induce IP-10 production and cell death, cells were then incubated with ginsenosides PPT and Re. The level of IP-10 and microRNA was determined by ELISA and real-time PCR respectively. Cell death was determined by MTT, TUNEL and flow cytometry. RESULTS: Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. In addition, ginsenoside-induced cytoprotection was reflected in the increase of cell viability. Data from flow cytometry analysis and TUNEL assay also showed that ginsenoside Re could protect ECs from H9N2/G1-induced apoptosis and DNA damage. CONCLUSIONS: This report further supports the traditional belief for immunomodulatory effects of ginseng, also demonstrated the partial protective mechanism of ginsenosides on avian influenza infection and its related endothelial dysfunction.</p>
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Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis.

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Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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